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PharmaNerd on Instagram: "Why Anticholinergics Cause Delirium in Older Adults In older adults, even common drugs can cause big problems. Anticholinergics block muscarinic receptors in both the body and the brain. In the elderly: • Baseline acetylcholine is already low • Blood–brain barrier is more permeable • Drug clearance is slower Further acetylcholine blockade leads to acute confusion, delirium, and hallucinations. Classic red flags: • Sudden confusion • Agitation • Dry mouth • Urinary reten
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