eLife

Exploiting fluctuations in gene expression to detect causal interactions between genes

Analyzing stochastic cell-to-cell variability can potentially reveal causal interactions in gene regulatory networks.
eLife

Immunoglobulin M regulates airway hyperresponsiveness independent of T helper 2 allergic inflammation

Immunoglobulin M has other functions beyond antibody class switching that have implications in asthma treatment.
eLife

High-Fidelity Neural Speech Reconstruction through an Efficient Acoustic-Linguistic Dual-Pathway Framework

This study presents a valuable advance in reconstructing naturalistic speech from intracranial ECoG data using a dual-pathway model. The evidence supporting the claims of the authors is solid, ...
eLife

Niche exclusion of a lung pathogen in mice with designed probiotic communities

This study reports a valuable method to predict the capacity of a candidate probiotic bacterium to metabolically outcompete a bacterial pathogen in the ecological niche of the murine respiratory tract ...
eLife

Early changes in the properties of CA3 engram cells explored with a novel viral tool in mice

A novel viral tool (FLEN) is designed, and used to monitor changes in the intrinsic and synaptic properties of engram cells quickly (3–6 hours) following encoding of a memory.
eLife

Single molecule counting detects low-copy glycine receptors in hippocampal and striatal synapses

The study presents convincing quantitative evidence, supported by appropriate negative controls, for the presence of low-abundance glycine receptors (GlyRs) within inhibitory synapses in telencephalic ...
eLife

Global molecular landscape of early MASLD progression in obesity

The authors provide a useful integrated analytical approach to investigating MASLD focused on diverse multiomic integration methods. The strength of evidence for this new resource is solid, as ...
eLife

Range geography and temperature variability explain cross-continental convergence in range and phenology shifts in a model insect taxon

Across continents, half of odonate species shifted both ranges and phenologies in response to climate warming, with southern species and those experiencing less temperature variability shifting ranges ...
eLife

A single-cell transcriptomic atlas reveals resident dendritic-like cells in the zebrafish brain parenchyma

The zebrafish brain combines a conserved heterogeneity of immune cells with a unique dendritic cell-like population.
eLife

Advantageous and disadvantageous inequality aversion can be taught through learning of others’ preferences

Like disadvantageous inequity aversion, advantageous inequity aversion can be learned by observing another’s fairness preferences.
eLife

Functional analysis across model systems implicates ribosomal proteins in growth and proliferation defects associated with hypoplastic left heart syndrome

Cross-species functional genomics identify ribosomal protein genes as key regulators of cardiomyocyte proliferation and heart development, implicating them as candidate modifiers for HLHS and ...
eLife

Experience-Dependent Plasticity: The little brain supervises learning in the big brain

The cerebellum (which is Latin for ‘little brain’) is the area of the brain in charge of fine motor coordination and balance, and it keeps our movements smooth and stable by predicting what our next ...