Studies in mice reveal a new target for potentially treating and preventing life-threatening cardiovascular complications in ...

In adults with insulin-treated type 2 diabetes, an automated insulin delivery system conferred lower HbA1c and improved time ...

Studies in mice reveal a new target for potentially treating and preventing life-threatening cardiovascular complications in ...

Glucagon-like peptide-1 (GLP-1) receptor agonists are incretin analogues that promote glucose-mediated insulin release and are used to treat type 2 diabetes mellitus and obesity. GLP-1 receptor ...

5-HT 2C R expression in the nucleus reticularis thalami (NRT) and VB was assessed by immunohistochemistry in adult Wistar rats, Genetic Absence Epilepsy Rats from Strasbourg (GAERS), and their ...

A research team of the University Medical Center Mainz has succeeded in observing for the first time how G protein-coupled receptors in living cells actually respond to activating substances. The ...

The etiology and pathogenesis of Autism Spectrum Disorder (ASD) are not yet clear. Gamma-aminobutyric acid (GABA), as an inhibitory neurotransmitter in the brain, is closely related to the ...

When it comes to brain proteins, small changes can make a dramatic difference. Researchers studying NMDA (N-methyl-D-aspartate) receptors, which are essential for learning, memory and moment-by-moment ...

Three distinct snapshots obtained with cryo-electron microscopy illustrate the arrangement of two of the four symmetrical subunits that make a functional NMDA receptor. During activation, as the ...

School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, China School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan ...

Thrombin, a serine protease with increased activity in people with diabetes, signals through PAR (protease-activated receptor) 1 and 4 on endothelial cells (ECs). On these cells, PAR1 is a ...

The brain’s cerebellum plays a key role in coordinating movement, balance, and cognition. Injury to the cerebellum can have a profound impact on basic motor skills, such as sitting, standing, and ...