Pregame analysis and predictions of the Boston Red Sox vs. New York Yankees MLB game to be played on August 21, 2025 on ESPN.

Not just another Yankees-Red Sox series, even. As far as regular-season series go, the stakes are about as high as they could be while the calendar is still in August, with the Yankees and Red Sox in the heat of a playoff race and about to play a four-game set that could go a long way in determining how the rest of the year plays out.

New York finished with five home runs Wednesday night and 14 in the series sweep of the Rays, tying a major league record (Reds, 1999) for most homers in a two-game series.

Giancarlo Stanton hit a pinch-hit, two-run home run in the top of the 10th inning to lift the Yankees to a 6-4 win over the Tampa Bay Rays on Wednesday night. Austin Wells followed with his second homer of the night,

Schlittler struck out Simpson, the Rays' leadoff man, looking at a 97-mph fastball on the inside corner to start a 1-2-3, 11-pitch bottom half and he made it six-up, six-down with an 11-pitch second, striking out Feduccia swinging at a 99-mph fastball to end the inning. Schlittler was at just 66 pitches through six.

Giancarlo Stanton hit a pinch-hit two-run homer in the 10th inning as the visiting New York Yankees completed a perfect five-game road trip Wednesday night with a 6-4 win over the Tampa Bay Rays.

The New York Yankees haven't been able to use star Aaron Judge in the field for weeks, and the injury is likely going to keep him from getting to 100 percent.

The New York Yankees will have Giancarlo Stanton back in the lineup after he missed three games with general soreness