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The last time cases reached outbreak status in South Dakota was in 2018, when there were a total of 169 cases in the state.
West Nile virus has been detected in Minnehaha County mosquito pools for the first time this season, the South Dakota Department of Health said.
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Cases of West Nile virus have been rising in North Dakota in recent weeks, and state health officials are reminding people to take precautions against mosquito bites.