eLife

High-Fidelity Neural Speech Reconstruction through an Efficient Acoustic-Linguistic Dual-Pathway Framework

This study presents a valuable advance in reconstructing naturalistic speech from intracranial ECoG data using a dual-pathway model. The evidence supporting the claims of the authors is solid, ...
eLife

Immunoglobulin M regulates airway hyperresponsiveness independent of T helper 2 allergic inflammation

Immunoglobulin M has other functions beyond antibody class switching that have implications in asthma treatment.
eLife

Early changes in the properties of CA3 engram cells explored with a novel viral tool in mice

A novel viral tool (FLEN) is designed, and used to monitor changes in the intrinsic and synaptic properties of engram cells quickly (3–6 hours) following encoding of a memory.
eLife

Global molecular landscape of early MASLD progression in obesity

The authors provide a useful integrated analytical approach to investigating MASLD focused on diverse multiomic integration methods. The strength of evidence for this new resource is solid, as ...
eLife

Single molecule counting detects low-copy glycine receptors in hippocampal and striatal synapses

The study presents convincing quantitative evidence, supported by appropriate negative controls, for the presence of low-abundance glycine receptors (GlyRs) within inhibitory synapses in telencephalic ...
eLife

A single-cell transcriptomic atlas reveals resident dendritic-like cells in the zebrafish brain parenchyma

The zebrafish brain combines a conserved heterogeneity of immune cells with a unique dendritic cell-like population.
eLife

Advantageous and disadvantageous inequality aversion can be taught through learning of others’ preferences

Like disadvantageous inequity aversion, advantageous inequity aversion can be learned by observing another’s fairness preferences.
eLife

Exploiting fluctuations in gene expression to detect causal interactions between genes

Analyzing stochastic cell-to-cell variability can potentially reveal causal interactions in gene regulatory networks.
eLife

Experience-Dependent Plasticity: The little brain supervises learning in the big brain

The cerebellum (which is Latin for ‘little brain’) is the area of the brain in charge of fine motor coordination and balance, and it keeps our movements smooth and stable by predicting what our next ...
eLife

Multiscale dynamical characterization of cortical brain states: from synchrony to asynchrony

We conclude that brain states are shaped by local circuit mechanisms, large-scale connectivity and neuromodulation. A unified multiscale theory of cortical dynamics is relevant not only for ...
eLife

State-dependent brain responsiveness, from local circuits to the whole brain

This correspondence between brain state and brain responsiveness (statedependent responses) is outlined at different scales from the cellular and circuit level, to the mesoscale and macroscale level.
eLife

Niche exclusion of a lung pathogen in mice with designed probiotic communities

This study reports a valuable method to predict the capacity of a candidate probiotic bacterium to metabolically outcompete a bacterial pathogen in the ecological niche of the murine respiratory tract ...