For patients with HRRm prostate cancer receiving Akeega and Zytiga with prednisone, quality of life remained at baseline.

“You can see that there was an initial reduction in the HR-QOL score in the niraparib arm, which may have been explained by the onset of the most frequently observed adverse events, which included ...

A new drug combination could significantly delay the progression of a life-threatening form of prostate cancer in men with ...

Niraparib combined with abiraterone acetate and prednisone improved rPFS in mCSPC patients with HRR gene alterations, especially BRCA1/2 mutations. The combination showed potential in reducing ...

Rathkopf presented the Late-breaking abstract 91 - Patient-reported outcomes (PROs) from AMPLITUDE, a randomized placebo-controlled phase 3 trial of niraparib (NIRA) and abiraterone acetate (AA) plus ...

Potential first-in-class, and industry-leading DNA polymerase Theta (Polθ) inhibitor, ART6043 demonstrated an attractive ...

Efficacy of Poly(ADP-ribose) Polymerase Inhibitors by Individual Genes in Homologous Recombination Repair Gene-Mutated Metastatic Castration-Resistant Prostate Cancer: A US Food and Drug ...

A few tiny molecular tweaks may explain why naked mole-rats live nearly ten times longer than similar species. Researchers ...

An international study has shown how and when entirely new gene mutations, known as de novo mutations, originate in dogs. A ...

While a typical mouse lives about four years, a naked mole-rat can live to nearly forty. That’s ten times longer than ...

These burrowing animals have a biological mechanism that does the opposite of what it does in humans: it repairs DNA instead ...

Scientists in Helsinki studied nearly 400 dog families to see how new DNA mutations arise in puppies. They found that older ...