Scientists have unearthed 188 previously unknown types of CRISPR systems buried in the genomes of simple microorganisms. Best known as a powerful gene-editing tool, CRISPR actually comes from an ...

As CRISPR continues to drive breakthroughs in medicine, agriculture, and synthetic biology, understanding its origins does more than tell an ancient story. It provides a blueprint for engineering the ...

The clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated proteins (Cas) system is a bacterial defense mechanism that uses RNA-guided enzymes to cut specific sequences ...

“I would venture to say that bacteria and archaea use everything that you can imagine for the purpose of defence — and then, some that you cannot,” said Eugene Koonin, an evolutionary biologist at the ...

The discovery of CRISPR-Cas gene editing technology has revolutionized biological research, providing new insights and opportunities for the advancement of several industries. However, the ...

The cryogenic electron microscope structure of the A4p-activated (green) CalpL protein filament (violet) from Candidatus Cloacimonas acidaminovorans (PDB ID: 9EYJ). CRISPR-Cas systems help to protect ...

CRISPR has a problem: an embarrassment of riches. Ever since the gene editing system rocketed to fame, scientists have been looking for variants with better precision and accuracy. One search method ...

A microscopic discovery will not only enable scientists to understand the microbial world around us but could also provide a new way to control CRISPR-Cas biotechnologies. An international team of ...

CRISPR, an acronym denoting clustered regularly interspaced short palindromic repeat, was identified by Nakata et al. in /US/en1987/US/en1 as repeat sequences interspaced by nucleotide spacers in the ...

CRISPR—Clustered Regularly Interspaced Short Palindromic Repeats—is the microbial world’s answer to adaptive immunity. Bacteria don’t generate antibodies when they are invaded by a pathogen and then ...