Medical Xpress

TGF-β signaling pathway mediates neuronal-intestinal mitochondrial stress response and lipid metabolism, finds study

Transforming growth factor-beta (TGF-β), a well-known morphogen, is recognized for its role in regulating growth and development. The study is published in the journal Nature Communications. The ...
EurekAlert!

Cathepsin K alleviates liver fibrosis by inhibiting the TGF-β/Smad signaling pathway and inducing hepatic stellate cell apoptosis

Suppression of the TGF-β/Smad pathway via a Smad7/Smurf2-dependent ubiquitination mechanism, and direct disruption of the apoptosis-resistant barrier in HSCs. This work extends the role of CTSK beyond ...
EurekAlert!

Investigation of HO-1 regulation of liver fibrosis related to nonalcoholic fatty liver disease through the SIRT1/TGF-ß/Smad3 pathway

HO-1 inhibits the activation of the TGF-ß/Smad3 pathway in NAFLD-related liver fibrosis through SIRT1. These findings provide insights into new therapeutic strategies for treating NAFLD-associated ...
Seeking Alpha

Incyte Corporation (INCY) Discusses ESMO Data on TGF-beta Receptor by PD-1 Bispecific in Colorectal Cancer and G12D Inhibitor in Pancreatic Cancer Transcript

We're going to get started. Thank you, everyone, for joining us here in Berlin, and there are many more of you that are online. Welcome to the solid tumor update that we're having at ESMO 2025. We're ...