Investigators led by Navdeep Chandel, Ph.D., the David W. Cugell, MD, Professor of Medicine in the Division of Pulmonary and Critical Care, have discovered how the metabolism of mitochondria supports ...
We owe a lot to tissue resident memory T cells (T RM). These specialized immune cells are among the body's first responders to disease. Rather than coursing through the bloodstream-as many T cells ...
T lymphocytes differentiate from naïve precursors upon antigen encounter into distinct effector and memory subsets. Following priming by antigen-presenting cells in lymphoid tissues, naïve CD4+ and ...
Memory T cells are a special type of white blood cell that "remember" past infections and vaccines, helping our bodies to quickly respond if we encounter the same germs again. These cells are found ...
Fine-tuning BACH2 dosage balances stemness and effector function to enhance antitumor T cell therapy
Adoptive T cell therapies are limited by poor persistence of transferred cells. Attempts to enhance persistence have focused on genetic induction of constitutively hyperactivated but potentially ...
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