The overexpression of EGFR is an established target in a number of cancers, and agents targeting this protein have been approved for the treatment of advanced-stage head and neck squamous-cell ...

Researchers showed that STAT3 plays an important role in the serotonergic system as a molecular mediator for controlling emotional reactivity, thereby establishing a mechanistic link between the ...

A new research paper was published in Oncotarget's, titled "Differential silencing of STAT3 isoforms leads to changes in STAT3 activation." These isoforms have been suggested as the reason for the ...

A new editorial perspective was published in Oncotarget, titled "STAT3 as a biologically relevant target in H3K27M-mutant diffuse midline glioma." Pediatric H3K27M-mutant diffuse midline gliomas (DMGs ...

SAN DIEGO, Oct. 17, 2023 (GLOBE NEWSWIRE) -- Recludix Pharma, a leader in platform approaches to discover inhibitors of challenging targets for inflammatory disease and cancer, announced that in a ...

In a study published online in advance of print in Stem Cells, Tufts researchers report that the STAT3 gene regulates cancer stem cells in brain cancer. Cancer stem cells have many characteristics of ...

Recludix Pharma Inc. has divulged proteolysis targeting chimeras (PROTACs) comprising cereblon (CRBN) ligands coupled to a signal transducer and activator of transcription 3 (STAT3) targeting moiety ...