Multiple-system atrophy is an adult-onset, fatal neurodegenerative disease characterized by progressive autonomic failure, parkinsonian features, and cerebellar and pyramidal features in various ...

Background Multiple system atrophy (MSA) is a progressive neurodegenerative disorder of unknown etiology, manifesting as combination of parkinsonism, cerebellar syndrome and dysautonomia.

α-synuclein is a neuronal protein involved in functions like vesicle trafficking and neurotransmitter release. It is typically found in abundance in a healthy brain. However, the aggregation of ...

Dr. Claudio M. de Gusmao: A 69-year-old man was evaluated in the neurology clinic of this hospital because of progressively worsening ataxia. The patient had been well until 9 years before this ...

(Cerebellar means “of the cerebellum” and is the sister word to cerebral, which means “of the cerebrum.") In his review, Fyfe highlights two recent studies which have identified distinctive patterns ...