As high-parameter T-cell profiling becomes increasingly central to translational research and biomarker discovery, there is ...

T lymphocytes differentiate from naïve precursors upon antigen encounter into distinct effector and memory subsets. Following priming by antigen-presenting cells in lymphoid tissues, naïve CD4+ and ...

Scientists analyzing human and mouse pancreatic lymph nodes (PLNs) and spleens have identified a distinct subset of CD4 memory helper T cells associated with type 1 diabetes (T1D). Reported by ...

However, details of the intervening steps, as researchers have learned in the past 65 years, are quite complex — certain cells carry the flu antigen to the immune system, specific immune cells respond ...

Fig. 5: TCF1 and BCL6 support the generation of Tsm, while BHLHE40 supports their differentiation into proinflammatory progeny in cGVHD target tissues. Fig. 6: Donor MHCII-mediated indirect ...

Shared TCR signatures in IBD linked to HLA-DRB1 reveal common immune mechanisms across ulcerative colitis and Crohn’s disease ...

T-bet expression is required for persistence of memory B cells that have rapid differentiation potential to become antibody-producing plasma cells in response to a second infection BIRMINGHAM, Ala. – ...