Nature

Physiological microbial exposure normalizes memory T cell surveillance of the brain and modifies host seizure outcomes

Recent studies have highlighted the presence of memory T cells in human brains, some of which are specific for peripheral infections. To address their potential origins, we used two models of ...
Nature

CXCR4 induces memory formation over exhaustion in CAR-T cells to achieve durable leukemia targeting

Chimeric antigen receptor (CAR)-T cell therapy has transformed the treatment of B-cell malignancies, but its success in acute myeloid leukemia (AML) remains limited. Durable responses depend on the ...
European Medical Journal

Shared T Cell Signatures Identified In IBD

Shared TCR signatures in IBD linked to HLA-DRB1 reveal common immune mechanisms across ulcerative colitis and Crohn’s disease ...
Medical Xpress

Mitochondria support T-cells proliferation and memory formation

Investigators led by Navdeep Chandel, Ph.D., the David W. Cugell, MD, Professor of Medicine in the Division of Pulmonary and Critical Care, have discovered how the metabolism of mitochondria supports ...
The Scientist

Innate Immune Cells Develop Memory with a T Cell Marker

For decades, dogma dictated that the immune system consisted of two separate branches. Cells of the innate system respond rapidly to molecular patterns shared by a broad array of pathogens. Meanwhile, ...