Kansas City Chiefs running back Isiah Pacheco (knee) suffered a knee injury late in his Week 8 contest against the Washington Commanders. He hasn't played since then -- he missed his Week 9 game, and Week 10 was the Chiefs' bye week.

"Isaiah Pacheco OUT for today’s game but Andy Reid telling me he avoided serious injury and should be back after the bye. Expect Kareem Hunt, Brashard Smith and Clyde Edwards-Helaire to carry the load #chiefs," Wolfson wrote on X.

One of the most exciting matchups from year to year in the Buffalo Bills vs. the Kansas City Chiefs will be taking place in the late afternoon time slot. Besides being a major rivalry game, there is a ton at stake as the 5-2 Bills look to push the 5-3 Chiefs out of their way for a hopeful Super Bowl run.

Washington Commanders running back Jacory Croskey-Merritt (22) is interviewed after the game against the Los Angeles Chargers at SoFi Stadium. / Jayne Kamin-Oncea-Imagn Images The running back outcomes for the Commanders and Chiefs have been sketchy all year.

See the best touchdowns from Week 10 of the 2025 NFL season. Highlights from the Week 10 matchup between the Philadelphia Eagles and the Green Bay Packers during the 2025 NFL season. Watch Green Bay Packers running back Josh Jacobs' best plays from his 107 ...

Pacheco gained 51 yards on 12 carries while catching one of three targets for no gain in Sunday's 30-17 win over Detroit. Pacheco finished Sunday's win as the Chiefs' leading rusher, garnering six more touches than veteran backup Kareem Hunt (6-23-0).