A new organoid model of the dopaminergic system sheds lights on its intricate functionality and potential implications for Parkinson's disease. The model replicates the dopaminergic system's structure ...

Collectively, these results unveil a key role for D-serine in the dopaminergic neuromodulation of glutamatergic transmission and PFC activity, findings with clear relevance to the pathogenesis and ...

There are three dopaminergic pathways, namely the striatonigral pathway (substantia nigra to caudate and putamen), the mesolimbic pathway (ventral tegmental area of midbrain to limbic areas of basal ...

GPR6, a G protein-coupled receptor, is primarily expressed in the medium spiny neurons of the striatum, specifically within the striatopallidal pathway. This pathway is heavily impacted by the loss of ...

Dyskinesia hampers the quality of life for most Parkinson's disease patients following several years of therapy. However, the severity of L-Dopa-induced dyskinesia (LID) varies between patients, being ...