A multi-institutional team of researchers led by Case Western Reserve University has identified a pattern of clustered genetic changes that appear to encourage growth of colorectal cancer tumors—a ...

Some sequences in the genome cause genes to be switched on or off. Until now, each of these gene switches, or so-called enhancers, was thought to have its own place on the DNA. Different enhancers are ...

The much-heralded Human Genome Project was a huge milestone for science, but most of that genetic blueprint came from one man from Buffalo, N.Y. On Wednesday, May 10, 2023, scientists announced they ...

For stem cells to differentiate into the appropriate cell-type, transcription factors (TFs) must be tailored to highly specific expression patterns of lineage-specific genes. Abnormalities in the ...

Despite spanning about three billion base pairs, the human genome is wrapped up tight in a highly organized fashion in the nucleus. This coordinated structure, in part, enables the cell to regulate ...

PhD graduate Dr. Renhe Luo won the 2024 Chairman’s Prize at the Gerstner Sloan Kettering Graduate School, affiliated with Memorial Sloan Kettering Cancer Center. This year’s $2,000 Chairman’s Prize ...

Neuronal specification, expansion and differentiation are tightly regulated by the concerted actions of transcription and chromatin modifying factors that are recruited to regulatory elements in the ...

An international team led by researchers with the Lawrence Berkeley National Laboratory (Berkeley Lab) has developed a new technique for identifying gene enhancers - sequences of DNA that act to ...

A study published in the journal Cell marks the first reported instance of generative AI designing synthetic molecules that can successfully control gene expression in healthy mammalian cells.