This new technique for studying cell receptors could have sweeping implications for drug development Date: August 27, 2024 Source: Rockefeller University Summary: Researchers created a tool ...

Protein complexes that adorn the surface of T cells—T cell receptors (TCRs)—act like molecular patrol officers, scanning cells for potential threats. When these receptors recognize short peptide ...

They could therefore be considered as activators of endogenous bitter receptors, which are located on intestinal and blood cells, for example. Explanation: Similar Structural Features ...

The methods described in the study provide new opportunities, not the least in the cancer field where T-cells are central to several promising forms of immunotherapy ", says Gunilla Karlsson Hedestam.

We designed a CD19-targeted chimeric antigen receptor (CAR) comprising a calibrated signaling module, termed 1XX, that differs from that of conventional CD28/CD3ζ and 4-1BB/CD3ζ CARs. Preclinical data ...