Mouse is the mammalian model of choice to study human health and disease due to its size, ease of breeding and the natural occurrence of conditions mimicking human pathology. Here we design and ...
Today, a plethora of biochemical and cell-based assays to experimentally test the biological activity of small organic compounds are at our disposal. These assay technologies are indispensable to a ...
PARP Inhibition in Prostate Cancer With Homologous Recombination Repair Alterations Literature searches were conducted in MEDLINE (via PubMed) and EMBASE to identify studies published between January ...
Biochemical assays isolate a defined molecular interaction, while cell-based screening assays capture integrated cellular responses. Each format offers unique advantages and limitations within HTS ...
Microbial assays are a technique to assess a compound’s potency or concentration. This is carried out by exposing microorganisms to the compound and determining its effect on them. Microbial assays ...
Overall Survival With Second-Line Pembrolizumab in Patients With Non–Small-Cell Lung Cancer: Randomized Phase III Clinical Trial Versus Propensity-Adjusted Real-World Data The ability of ...
Leukemia is an umbrella term for multiple different cancers that form in the blood, one such member of the leukemia family being chronic myelogenous leukemia (CML). CML is caused by a chromosomal ...
Spanning the Gap between Synthetic Lipid Chemisty and Signal Transduction Biology Many scientists are familiar with lipids as hydrophobic molecules that form biological cell membranes. However, ...
Screening cascades form the structural backbone of modern high-throughput screening strategies in drug discovery. In an environment where millions of compounds can be assessed against biological ...
Some results have been hidden because they may be inaccessible to you
Show inaccessible results