It's the Mac Jones show for the 49ers for at least one more week as Brock Purdy is out with a toe injury that's caused him to miss all but two contests this season. Jones is 4-1 as a starter in Purdy's absence. The 49ers will also be without receiver Ricky Pearsall once again as he battles a knee injury.

Marcus Mariota will start in place of Daniels as the Commanders try and avoid falling to 3-5 overall. Unfortunately, fans won’t get to see Daniels go toe-to-toe against Mahomes, and the latter is disappointed by that.